GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs8102137 | 1 | rs62104478 | chr19:30295306 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 4.02 | 6.98E-5 | Bladder cancer |
| BLCA | cis | rs60843830 | 1 | rs62114497 | chr2:214837 | SH3YL1 | chr2:218138-264810:- | -0.42 | -10.8 | 6.68E-24 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs62114501 | chr2:231741 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.66 | 4.4E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs62114505 | chr2:242426 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.78 | 1.53E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs62114544 | chr2:269679 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.79 | 1.36E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs62114548 | chr2:274672 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.71 | 2.68E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs55883249 | 1 | rs62119428 | chr2:9743332 | ADAM17 | chr2:9629413-9695917:- | -0.19 | -3.98 | 8.15E-5 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| BLCA | cis | rs55883249 | 1 | rs62119429 | chr2:9743585 | ADAM17 | chr2:9629413-9695917:- | -0.19 | -3.98 | 8.15E-5 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| BLCA | cis | rs17818399 | 1 | rs62136864 | chr2:46829124 | ATP6V1E2 | chr2:46738988-46769696:- | -0.27 | -4.35 | 1.77E-5 | Height |
| BLCA | cis | rs6708331 | 1 | rs62151174 | chr2:70363968 | FAM136A | chr2:70523109-70529220:- | -0.23 | -3.88 | 0.000125 | Obesity-related traits |
| BLCA | cis | rs9309473 | 1 | rs62151652 | chr2:73700131 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.22 | 2.91E-7 | Metabolite levels |
| BLCA | cis | rs10935120 | 1 | rs62269547 | chr3:134214042 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.74 | 8.8E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs62269547 | chr3:134214042 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 4.02 | 7.02E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs62271513 | chr3:134298412 | ANAPC13 | chr3:134196547-134204865:- | -0.48 | -7.73 | 9.49E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs62271514 | chr3:134298554 | ANAPC13 | chr3:134196547-134204865:- | -0.48 | -7.73 | 9.49E-14 | Height |